Abstract
SAR for a novel series of dopamine D4 receptor ligands is shown. Very selective, highly potent compounds like 1-(2-pyrimidinyl)-4-(3-(3-thienyl)-benzyl)-piperazine (5f) and 2-(4-(1-fluorenylmethyl)-1-piperazinyl)-pyrimidine (8c) were obtained.
MeSH terms
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Animals
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Dopamine Antagonists / metabolism
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Dopamine Antagonists / pharmacology
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Ligands
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Methylamines / chemistry*
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Methylamines / metabolism
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Methylamines / pharmacology
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Mice
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Receptors, Dopamine D2 / metabolism*
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Receptors, Dopamine D4
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Structure-Activity Relationship
Substances
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Dopamine Antagonists
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Drd4 protein, mouse
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Ligands
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Methylamines
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Receptors, Dopamine D2
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Receptors, Dopamine D4
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methylamine